AmritX
Therapeutic interventions to prevent and treat infection.
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About Us
We have developed a drug design algorithm, integrated within our therapeutic discovery platform, CANDO (Computational Analysis of Novel Drug Opportunities), which leverages multiscale data to rapidly generate unique, effective, and safe drugs de novo. The novelty of this approach lies in the use of full organismal proteomes to tailor molecules for specific therapeutic uses, while considering toxicity and other pharmacological properties. This approach is in direct contrast to traditional drug discovery pipelines in which a single protein target is used in a large-scale screen of compounds/drugs for a single disease/indication.
Leadership
Ram Samudrala, Ph.D.
CEO and co-founder
William Mangione, Ph.D.
CSO and co-founder
Brennan Overhoff
COO and co-founder
Zackary Falls, Ph.D.
Co-founder
The AmritX team has collectively been a part of a twenty year research programme modeling protein and proteome structure, function, interaction, design, and evolution at multiple scales. With more than 140 publications in journals such as Science, Nature, PLoS Biology, the Proceedings of the National Academy of Sciences, and the Journal of the American Medical Association and numerous industry collaborations, the team is well equipped with the academic and commercial experience needed to attack some of the biggest health threats of our time.
Media and Publications
Shotgun Drug Repurposing Aids Fight Against COVID-19
University at Buffalo School of Medicine2020 NCATS ASPIRE Reduction-to-Practice Challenge Winners
National Center for Advancing Translational Sciencescando.py: Open Source Software for Predictive Bioanalytics of Large Scale Drug–Protein–Disease Data
Pipeline
Lead design
Lead synthesis
Preclinical
Phase I
Phase II
Phase III
Fungal infections
Non-small cell lung cancer
Neoplastic diseases